Down Syndrome Research Today is a free monthly online journal that collates and summarizes the latest research about Down Syndrome, including details on education, symptoms, treatment, information.

Endometrial cancer arising in both horns of didelphys uterus in a Down's syndrome woman.

Fanfani F, Fagotti A, Restaino G, Guerriero M, Scambia G

Division of Gynecologic Oncology, Catholic University of Sacred Heart, Campobasso, Italy.

BACKGROUND: There are only few reports of endometrial cancer arising in patients with uterine malformations. Down's syndrome is characterized by a reduced risk of solid tumors, and there are no reports about its correlation with uterine malformations. CASE: An endometrial adenocarcinoma arising in both horns of a didelphys uterus of a Down's syndrome woman. CONCLUSION: Uterine malformations and genetical disorders may cause a delayed diagnosis of gynecological cancers. Gynecological examination in asymptomatic patients and differential diagnosis in abnormal uterine bleeding patients should be considered.

Published 25 May 2006 in Gynecol Oncol, 101(3): 537-9.
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