Down Syndrome Research Today is a free monthly online journal that collates and summarizes the latest research about Down Syndrome, including details on education, symptoms, treatment, information.

Variation over time in medical conditions and health service utilization of children with Down syndrome.

Thomas K, Bourke J, Girdler S, Bebbington A, Jacoby P, Leonard H

Department of Occupational Therapy, School of Exercise, Biomedical, and Health Sciences, Edith Cowan University, West Perth, Western Australia.

Published 17 January 2011 in J Pediatr, 158(2): 194-200.e1.
Full-text of this article is available online (may require subscription).

Articles on Down Syndrome published 6 January 2011:

Static and dynamic measurements of accommodation in individuals with down syndrome.   Invest Ophthalmol Vis Sci, 52(1): 310-7.

[Abstract] [Full-text]

Articles on Down Syndrome published 28 December 2010:

Effects of combined aerobic and resistance exercise training in adults with and without Down syndrome.   Arch Phys Med Rehabil, 92(1): 37-45.

[Abstract] [Full-text]

Articles on Down Syndrome published 20 December 2010:

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies.   Fertil Steril, 95(1): 378-81.

The maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) were reduced in hormonally stimulated pregnancies in the in vitro fertilization and intracytoplasmic sperm injection groups (N=176; PAPP-A: 0.82) and in the entire assisted reproduction group (N=282; PAPP-A: 0.83) as compared with controls (N=24,783; PAPP-A: 0.94). However, the false-positive rate of first-trimester combined screenings was not statistically significantly increased in assisted reproduction pregnancies ... [Abstract] [Full-text]

Articles on Down Syndrome published 14 December 2010:

Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case.   Hum Pathol, 42(1): 141-5.

Transient abnormal myelopoiesis in neonates with Down syndrome is an unusual leukemia that spontaneously regresses within several months of life and is thought to arise in the fetal liver. It is largely unknown how the leukemic blasts proliferate and differentiate in fetal tissues. We report the histopathological findings of an autopsy case of a stillbirth with transient abnormal myelopoiesis. Blood vessels in almost all organs were filled with immature leukemic cells, most of which expressed ... [Abstract] [Full-text]

Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case.   Hum Pathol, 42(1): 141-5.

Transient abnormal myelopoiesis in neonates with Down syndrome is an unusual leukemia that spontaneously regresses within several months of life and is thought to arise in the fetal liver. It is largely unknown how the leukemic blasts proliferate and differentiate in fetal tissues. We report the histopathological findings of an autopsy case of a stillbirth with transient abnormal myelopoiesis. Blood vessels in almost all organs were filled with immature leukemic cells, most of which expressed ... [Abstract] [Full-text]

Articles on Down Syndrome published 22 November 2010:

Prevalence of iron deficiency in children with Down syndrome.   J Pediatr, 157(6): 967-971.e1.

[Abstract] [Full-text]

Articles on Down Syndrome published 11 November 2010:

Down syndrome: from understanding the neurobiology to therapy.   J Neurosci, 30(45): 14943-5.

Down syndrome (DS) is the most common example of a neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of human chromosome 21 producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. Understanding the consequences of dosage imbalance attributable to trisomy 21 (T21) has accelerated because of recent advances in genome sequencing, comparative genome analysis, functional genome exploration, and ... [Abstract] [Full-text]

Articles on Down Syndrome published 9 November 2010:

Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down syndrome.   Am J Cardiol, 106(10): 1512-6.

Adults with Down syndrome (DS) residing in large institutional settings possess low levels of atherosclerosis. The purpose of this study was to determine whether community-residing adults with DS possess less atherosclerosis than adults without DS. The second purpose was to examine the relation between cardiovascular disease risk factors and intima-media thickness (IMT), a measure of atherosclerosis, in patients with DS. B-mode images of the left common carotid artery were collected to assess ... [Abstract] [Full-text]

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